{"id":2164,"date":"2018-09-25T11:43:11","date_gmt":"2018-09-25T11:43:11","guid":{"rendered":"https:\/\/www.science.nus.edu.sg\/?p=2164"},"modified":"2020-01-30T15:06:51","modified_gmt":"2020-01-30T15:06:51","slug":"urea-absorbing-ability-of-giant-clams","status":"publish","type":"post","link":"https:\/\/www.science.nus.edu.sg\/blog\/2018\/09\/urea-absorbing-ability-of-giant-clams\/","title":{"rendered":"Urea-absorbing ability of giant clams"},"content":{"rendered":"<p>25 Sep 2018. NUS biologists have discovered that the fluted giant clam absorbs urea from its surroundings and the absorption rate is enhanced by exposure to light.<\/p>\n<p>Giant clams live in nutrient-poor reef waters of the Indo-Pacific region and rely on symbiotic zooxanthellae for nutrients. Zooxanthellae are photosynthetic algae and behave like tiny plant-like organisms that live in the tissues of many animals such as giant clams and some corals. The zooxanthellae provide nutrients to the giant clams in return for the accommodation given to them. As the zooxanthellae are nitrogen-deficient, the host clam has to absorb exogenous nitrogen from the surrounding seawater and supply it to them for producing nutrients. In seawater, dissolved inorganic nitrogen is available in the form of ammonium, nitrite and nitrate, while dissolved organic nitrogen is available as urea and amino acids.<\/p>\n<p>A research team led by Prof Alex IP, from the Department of Biological Sciences, NUS has reported for the first time that apart from inorganic nitrogen dissolved in seawater, the fluted giant clam, <em>Tridacna squamosa<\/em>, can also obtain nitrogen by absorbing urea from its surroundings. In their experiments, the researchers found that the fluted giant clam absorbed about 1.6 times more urea when it is exposed to light (visible) than in the dark. They also found a protein similar to DUR3 being produced in the fluted giant clam\u2019s gill. DUR3 is a type of protein that facilitates the movement of absorbed urea within organisms. The level of this DUR3-like protein in the gill increases by about eight times over a period of 12 hours when the fluted giant clam is exposed to light.\u00a0 Urea is usually an excretory nitrogenous waste in animals, and most animals possess transporters (which are usually made of proteins) to facilitate urea excretion. As animals cannot metabolise urea, it is intriguing to find aquatic animals which absorb it from their surroundings. The research findings provide insights into supplementing giant clams with urea as organic nitrogen to facilitate their growth and development during aquaculture, which will speed up the reseeding of giant clams back to the coral reefs to compensate for their dwindling population.<\/p>\n<p>Prof Ip said, \u201cOur findings show that the fluted giant clam is capable of light-enhanced urea absorption, and its gill expresses a DUR3-like protein of animal origin. This uncommon phenomenon could be a result of the selective advantage of the close and long-term symbiotic interactions between the giant clam and zooxanthellae.\u201d<\/p>\n<p>\u201cThe degradation of the absorbed urea and the utilisation of the resulting ammonia and carbon dioxide are only feasible through the collaboration between the host clam and its symbiotic zooxanthellae, as the latter possesses the enzyme urease for urea degradation. The symbiotic zooxanthellae can metabolise the absorbed urea to ammonia and carbon dioxide to support amino acid synthesis and photosynthesis, which is essential for the clam,\u201d added Prof Ip.<\/p>\n<p>The team is conducting further research to characterise the urea-active transporter and urease from zooxanthellae residing in the colourful outer mantle of fluted giant clams, and to examine effects of light exposure on their gene and protein expression levels.<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.science.nus.edu.sg\/wp-content\/uploads\/2019\/11\/162._Alex_Ip_DBS_20180606_1.jpg\" \/><\/p>\n<p><em>Tridacna squamosa<\/em>, known commonly as the fluted giant clam, is a clam species that can be found in the South Pacific and Indian Ocean, near shallow coral reefs.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Reference<\/strong><\/p>\n<p>Chan CYL; Hiong KC; Boo MV; Choo CYL; Wong WP; Chew SF; Ip YK*, &#8220;Light exposure enhances urea absorption in the fluted giant clam, Tridacna squamosa, and up-regulates the protein abundance of a light-dependent urea active transporter, DUR3-like, in its ctenidium&#8221; JOURNAL OF EXPERIMENTAL BIOLOGY Volume: 221 Issue: 8 Article Number: jeb176313 DOI: 10.1242\/jeb.176313 Published: 2018.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>25 Sep 2018. NUS biologists have discovered that the fluted giant clam absorbs urea from its surroundings and the absorption&#8230;<\/p>\n","protected":false},"author":1,"featured_media":7260,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[54,13],"tags":[],"class_list":["post-2164","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mechanobiology","category-research-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Urea-absorbing ability of giant clams - NUS Faculty of Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.science.nus.edu.sg\/blog\/2018\/09\/urea-absorbing-ability-of-giant-clams\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Urea-absorbing ability of giant clams\" \/>\n<meta property=\"og:description\" content=\"25 Sep 2018. 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