Biological Sciences

The Department of Biological Sciences continued to excel in academic, research and collaborative endeavours, such as regional biodiversity partnerships, to address key global challenges like climate change, environmental degradation and human health.

We jointly organised two international conferences, which further elevated our standing and visibility in the global scientific community. These were the 5th Asia Pacific Coral Reef Symposium and the 12th General Meeting of the International Proteolysis Society, both of which took place in June 2023.

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Future Talent

We provide diverse educational pathways catering to our undergraduate students’ different learning interests. This year, we graduated our first cohort from our partner University of Dundee (UoD), Scotland, United Kingdom, upon completion of the Joint Degree Programme in NUS Life Sciences with UoD, which offers students foremost training in life sciences from two leading universities in this field.

We will launch a Minor in Botany this year, which provides students knowledge and skills in plant and horticultural sciences under an industry-relevant teaching collaboration with the Singapore Botanic Gardens. This programme will also meet growing manpower needs in environmental sustainability and conservation.

Our Master of Science (MSc) in Biodiversity Conservation and Nature-based Climate Solutions programme has grown, with 43 international students. Conservation International (CI) gifted scholarships to support this MSc programme, which trains environmental leaders for the future. Under this scholarship, students will work in organisations committed to promoting biodiversity conservation and sustainability.

We received a $2 million gift under the Percy McNiece Doctor of Philosophy (PhD) Scholarship to support outstanding postgraduate students pursuing biodiversity research. TAN Zhi Wan, the first recipient, works on Indochinese freshwater potamid crabs.

The MSc in Biotechnology’s revised curriculum, with an elective capstone project, allows students to choose a 100% coursework path or a mixed coursework / research path towards their MSc degree. The experience in our core course, BL5601 Case Studies in Biotechnology, inspired four of our MSc students to form a team for the Fuel Asia Innovation Challenge (2022). We also held our first annual Biotechnology Networking Day, where students heard from industry professionals about opportunities and challenges in this rapidly growing field.

The AMGEN Scholars Programme allows undergraduate students to participate in advanced research at top institutions worldwide. We hosted 23 scholars for a two-month internship at NUS and 86 scholars from Japan and China for a symposium in August 2023. We were awarded a new phase to continue running the programme for another four years, focusing on undergraduate students from Asia.

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Future Solutions

We received around $40 million in research funding in Academic Year 2022 / 2023 to address pressing issues such as sustainability, and health and diseases, to name a few. Recently, Assoc Prof HUANG Danwei was awarded a grant under the Marine Climate Change Science programme to work on enhancing coral reef resilience in the face of climate change.

Improving plant resilience against droughts

Plants lose around 95% of absorbed water through tiny pores called stomata. Assoc Prof LAU On Sun’s team recently discovered how plants reduce the formation of these pores to survive drought. The hormone abscisic acid (ABA) destabilises a key protein in plants called SPEECHLESS (SPCH) to suppress stomatal formation and prevent water loss. Manipulating this process could improve drought tolerance, optimise water usage and enhance crop growth. This finding is important for food security, given more frequent droughts due to global warming. This study was published in Science Advances (October 2022).

Improving energy efficiency of water purification

Water scarcity is a global problem and purification methods are expensive and energy intensive. Biomimetic membranes containing artificial water channels (AWCs) can be a solution. Prof Prakash KUMAR’s team designed a novel AWC using a special protein-mimic (oligourea foldamers) that can self-assemble into a channel with a pore. When incorporated into a lipid membrane, this AWC permits selective transport of water across the membrane, rejecting ions, thereby offering potential benefits for water purification applications. This study was published in Chem (May 2023).

How different plants and animals coexist

Two main theories exist on the coexistence of plants and animals: one states that specific roles or the ‘niche’ of species determine the maximum number of species but that observed numbers may be lower if immigration is low; the other suggests that niches determine the minimum number of species and observed numbers are usually higher because of ongoing immigration. Assoc Prof Ryan CHISHOLM’s team tested these ideas in an intertidal system in Singapore and found evidence supporting the latter theory. Under low immigration, the diversity was at a minimum value of approximately five species; when immigration was high, the diversity greatly exceeded this. The approach can be applied to understand species coexistence in other ecosystems. This study was published in Nature (June 2023).

Potential for new antibiotics for cell lysis

Asst Prof LUO Min’s team studied how bacteria divide and the specific molecules involved, focusing on two important players called ‘amidases’ and the ‘FtsEX complex’. This helped them better understand how amidases are activated, which is crucial for bacteria to split and grow. This finding could be important for developing new antibiotics that target bacterial cell lysis, or cellular disruption, to fight bacterial infections. These studies were published in the Proceedings of the National Academy of Sciences (May 2023) and also accepted for publication in Nature Communications (November 2023).

Understanding HACE1, a tumour suppressor

Prof SIVARAMAN’s team studied HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1), a tumour suppressor protein, using cryogenic electron microscopy. They discovered that HACE1’s ability to attach ubiquitin to other proteins is hindered when it exists in dimeric form, compared to monomers. The study emphasises the significance of ankyrin repeats and the middle domain in recognising and binding the substrate RAC1 (Ras-related C3 botulinum toxin substrate 1), affecting its activity. These findings offer crucial insights for potential cancer treatments. This study was published in Advanced Science (August 2023).

Our faculty members are recognised for the impact and quality of their research. Prof YU Hao (left) was appointed as a Provost Chair Professor in 2023 for his work in advancing the field of plant development.

Asst Prof HU Chunyi (right) was appointed as a Presidential Young Professor and is recognised as a talented young scientist working on new molecular tools that can edit genes with high precision, offering potential therapies for genetic diseases.

Three of our students also received the Outstanding Undergraduate Researcher Prize (OURP), which recognises the best undergraduate researchers.

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Future Society

Singapore edged out 75 countries to emerge as the top-performing country at the 34th International Biology Olympiad (IBO) (2023) held in the United Arab Emirates in July. Team Singapore, trained and mentored by our faculty members, achieved four Gold medals. This marks the fourth time in the last 12 years that Team Singapore earned the highest country ranking in the IBOs.

Our alumni also make impactful contributions in a wide range of areas.