Biological Sciences

The Department of Biological Sciences continued to excel in academic, research and collaborative endeavours, such as regional biodiversity partnerships, to address key global challenges like climate change, environmental degradation and human health.

We jointly organised two international conferences, which further elevated our standing and visibility in the global scientific community. These were the 5th Asia Pacific Coral Reef Symposium and the 12th General Meeting of the International Proteolysis Society, both of which took place in June 2023.

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Future Talent

We provide diverse educational pathways catering to our undergraduate students’ different learning interests. This year, we graduated our first cohort from our partner University of Dundee (UoD), Scotland, United Kingdom, upon completion of the Joint Degree Programme in NUS Life Sciences with UoD, which offers students foremost training in life sciences from two leading universities in this field.

We will launch a Minor in Botany this year, which provides students knowledge and skills in plant and horticultural sciences under an industry-relevant teaching collaboration with the Singapore Botanic Gardens. This programme will also meet growing manpower needs in environmental sustainability and conservation.

Our Master of Science (MSc) in Biodiversity Conservation and Nature-based Climate Solutions programme has grown, with 43 international students. Conservation International (CI) gifted scholarships to support this MSc programme, which trains environmental leaders for the future. Under this scholarship, students will work in organisations committed to promoting biodiversity conservation and sustainability.

We received a $2 million gift under the Percy McNiece Doctor of Philosophy (PhD) Scholarship to support outstanding postgraduate students pursuing biodiversity research. TAN Zhi Wan, the first recipient, works on Indochinese freshwater potamid crabs.

The MSc in Biotechnology’s revised curriculum, with an elective capstone project, allows students to choose a 100% coursework path or a mixed coursework / research path towards their MSc degree. The experience in our core course, BL5601 Case Studies in Biotechnology, inspired four of our MSc students to form a team for the Fuel Asia Innovation Challenge (2022). We also held our first annual Biotechnology Networking Day, where students heard from industry professionals about opportunities and challenges in this rapidly growing field.

The AMGEN Scholars Programme allows undergraduate students to participate in advanced research at top institutions worldwide. We hosted 23 scholars for a two-month internship at NUS and 86 scholars from Japan and China for a symposium in August 2023. We were awarded a new phase to continue running the programme for another four years, focusing on undergraduate students from Asia.

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Future Solutions

We received around $40 million in research funding in Academic Year 2022 / 2023 to address pressing issues such as sustainability, and health and diseases, to name a few. Recently, Assoc Prof HUANG Danwei was awarded a grant under the Marine Climate Change Science programme to work on enhancing coral reef resilience in the face of climate change.

Improving plant resilience against droughts

Plants lose around 95% of absorbed water through tiny pores called stomata. Assoc Prof LAU On Sun’s team recently discovered how plants reduce the formation of these pores to survive drought. The hormone abscisic acid (ABA) destabilises a key protein in plants called SPEECHLESS (SPCH) to suppress stomatal formation and prevent water loss. Manipulating this process could improve drought tolerance, optimise water usage and enhance crop growth. This finding is important for food security, given more frequent droughts due to global warming. This study was published in Science Advances (October 2022).

Improving energy efficiency of water purification

Water scarcity is a global problem and purification methods are expensive and energy intensive. Biomimetic membranes containing artificial water channels (AWCs) can be a solution. Prof Prakash KUMAR’s team designed a novel AWC using a special protein-mimic (oligourea foldamers) that can self-assemble into a channel with a pore. When incorporated into a lipid membrane, this AWC permits selective transport of water across the membrane, rejecting ions, thereby offering potential benefits for water purification applications. This study was published in Chem (May 2023).

How different plants and animals coexist

Two main theories exist on the coexistence of plants and animals: one states that specific roles or the ‘niche’ of species determine the maximum number of species but that observed numbers may be lower if immigration is low; the other suggests that niches determine the minimum number of species and observed numbers are usually higher because of ongoing immigration. Assoc Prof Ryan CHISHOLM’s team tested these ideas in an intertidal system in Singapore and found evidence supporting the latter theory. Under low immigration, the diversity was at a minimum value of approximately five species; when immigration was high, the diversity greatly exceeded this. The approach can be applied to understand species coexistence in other ecosystems. This study was published in Nature (June 2023).

Potential for new antibiotics for cell lysis

Asst Prof LUO Min’s team studied how bacteria divide and the specific molecules involved, focusing on two important players called ‘amidases’ and the ‘FtsEX complex’. This helped them better understand how amidases are activated, which is crucial for bacteria to split and grow. This finding could be important for developing new antibiotics that target bacterial cell lysis, or cellular disruption, to fight bacterial infections. These studies were published in the Proceedings of the National Academy of Sciences (May 2023) and also accepted for publication in Nature Communications (November 2023).

Understanding HACE1, a tumour suppressor

Prof SIVARAMAN’s team studied HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1), a tumour suppressor protein, using cryogenic electron microscopy. They discovered that HACE1’s ability to attach ubiquitin to other proteins is hindered when it exists in dimeric form, compared to monomers. The study emphasises the significance of ankyrin repeats and the middle domain in recognising and binding the substrate RAC1 (Ras-related C3 botulinum toxin substrate 1), affecting its activity. These findings offer crucial insights for potential cancer treatments. This study was published in Advanced Science (August 2023).

Our faculty members are recognised for the impact and quality of their research. Prof YU Hao (left) was appointed as a Provost Chair Professor in 2023 for his work in advancing the field of plant development.

Asst Prof HU Chunyi (right) was appointed as a Presidential Young Professor and is recognised as a talented young scientist working on new molecular tools that can edit genes with high precision, offering potential therapies for genetic diseases.

Three of our students also received the Outstanding Undergraduate Researcher Prize (OURP), which recognises the best undergraduate researchers.

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Future Society

Singapore edged out 75 countries to emerge as the top-performing country at the 34th International Biology Olympiad (IBO) (2023) held in the United Arab Emirates in July. Team Singapore, trained and mentored by our faculty members, achieved four Gold medals. This marks the fourth time in the last 12 years that Team Singapore earned the highest country ranking in the IBOs.

Our alumni also make impactful contributions in a wide range of areas.

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Providing inclusive and accessible education

“I acquired deeper knowledge about conservation and gained theoretical and practical foundations from NUS’ graduate programme. Meeting CI was an inspiring experience on how international non-governmental organisations work to protect nature.”

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Assistive technology for dementia patients

“Our device provides real-time support to dementia patients and alleviates the burden and stress of caregivers.”

A team of four MSc Biotechnology students edged out over 400 participants to emerge second in the Fuel Asia Innovation Challenge (2022), which focuses on digital health solutions.

Their project addresses the often-neglected issue of falls and accidents among persons with dementia. This was inspired by the personal experience of team lead Ms Shristi DEBATA‘s grandmother, a dementia patient who suffered a fatal accident. The team engaged with medical professionals and caregivers to identify gaps in current technology. Their solution addresses these gaps by incorporating tamper-resistant features, emphasising user comfort and enabling 24 / 7 remote monitoring to connect patients with caregivers.

This technology holds potential for broader caregiving applications in the future. 

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Budding scientist

Year 2 Environmental Studies student Ivan NEO, who also reads a Minor In Geographical Information Systems, received the OURP for his project on pygmy grasshoppers in Singapore’s last substantial freshwater swamp habitat, the Nee Soon Swamp Forest (NSSF). His study documented, for the first time, the diagnostic features, habitat associations and notes on the natural history of each species of pygmy grasshopper found in NSSF. His work informs future efforts to clarify the taxonomy of pygmy grasshoppers and to monitor NSSF’s tetrigid biodiversity as well as its ecosystem health.

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Budding scientist

Year 3 Life Sciences student DONG Hoang Van, who also reads a Minor in Bioinformatics, received the OURP for discovering how extracellular vesicles (EVs) derived from red blood cells (RBCEVs) can deliver nucleic acids to recipient cells, to regulate gene activity. He effectively demonstrated how RBCEVs incorporating synthetic nucleic acids suppress the COVID-19 virus. These findings offer the potential to develop novel therapeutic delivery methods using RBCEVs.

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Budding scientist

Year 4 student G Suthershinii, who reads Double Majors in Life Sciences and Psychology, received the OURP for successfully engineering and characterising the structure and functions of a tiny dengue virus nonstructural protein 1 (NS1) with a fluorescent tag. NS1 is a multifunctional protein secreted in infected host cells. Her work paves the way for further studies on dengue infections and the potential for therapeutic targets to treat dengue infections.

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Saving Asia’s threatened birds

“I look forward to working with colleagues all around Asia to secure the protection of our region’s most threatened bird species.”

Life Sciences alumnus (2008) Dr YONG Ding Li, a conservation biologist with the United Kingdom-based non-governmental organisation (NGO) BirdLife International, is the first in Asia to receive the prestigious Early Career Conservationist Award. He was recognised for his extensive work on protecting wetlands and migratory species, such as the spoon-billed sandpiper and Nordmann’s greenshank, in collaboration with local NGOs and other stakeholders in Malaysia, Cambodia, Vietnam, Indonesia and Myanmar. He has also supported efforts to recognise and establish United Nations Educational, Scientific and Cultural Organization (UNESCO) World Heritage sites at key wetlands in China and South Korea.

The award by the Society for Conservation Biology is given to recipients who contribute significantly to conservation efforts within 10 years of completing their studies.

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New bent-toed gecko species in Timor-Leste

“We have barely scratched the surface of Timor-Leste’s biodiversity. New discoveries can have profound impacts on conservation and policy-making.”

In August 2022, we led an expedition to Timor-Leste in collaboration with Conservation International and the government of Timor-Leste. The Museum’s herpetologist, Dr CHAN Kin Onn, discovered a new species of bent-toed gecko which was named Cyrtodactylus santana, in reference to the Nino Konis Santana National Park, in which the gecko was discovered.